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Issue 86, 2012
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An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase

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Abstract

Phosphorylation is an abundant post-translational modification involved in a myriad of cell signaling pathways. Herein, we have engineered the class II lantipeptide synthetase ProcM to generate a variety of peptides containing O-phosphoserine (pSer) and O-phosphothreonine (pThr) residues, either in vitro or in vivo.

Graphical abstract: An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase

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Publication details

The article was received on 08 Jun 2012, accepted on 11 Sep 2012 and first published on 21 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC34138G
Citation: Chem. Commun., 2012,48, 10615-10617
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    An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase

    G. N. Thibodeaux and W. A. van der Donk, Chem. Commun., 2012, 48, 10615
    DOI: 10.1039/C2CC34138G

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