Issue 68, 2012
From the journal:

Chemical Communications

Enhanced enantioselectivity of 3-methylcyclohexanone by mixed diol host compounds†

Luigi R. Nassimbeni,*a   Hong Sua  and  Tanith-Lea Curtina  

* Corresponding authors

a Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
E-mail: Luigi.Nassimbeni@uct.ac.za
Fax: +27-21-6505419
Tel: +27-21-6505893

Abstract

3-Methylcyclohexanone is only partially resolved by crystallisation with a chiral diol host compound (ee 40%), but when recrystallised from an equimolar mixture of the chiral diol host and a similar but achiral host we obtain complete resolution. The latter host acts as a nucleation inhibitor and the enhanced resolution is attributed to kinetic effects.

Graphical abstract: Enhanced enantioselectivity of 3-methylcyclohexanone by mixed diol host compounds

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC34118B
Article type
Communication
Submitted
08 Jun 2012
Accepted
29 Jun 2012
First published
04 Jul 2012

Chem. Commun., 2012,48, 8526-8528

Permissions

Request permissions

Enhanced enantioselectivity of 3-methylcyclohexanone by mixed diol host compounds

L. R. Nassimbeni, H. Su and T. Curtin, Chem. Commun., 2012, 48, 8526 DOI: 10.1039/C2CC34118B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements