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Issue 68, 2012
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A lateral flow biosensor for detection of single nucleotide polymorphism by circular strand displacement reaction

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Abstract

A lateral flow biosensor for detection of single nucleotide polymorphism based on circular strand displacement reaction (CSDPR) has been developed. Taking advantage of high fidelity of T4 DNA ligase, signal amplification by CSDPR, and the optical properties of gold nanoparticles, this assay has reached a detection limit of 0.01 fM.

Graphical abstract: A lateral flow biosensor for detection of single nucleotide polymorphism by circular strand displacement reaction

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Publication details

The article was received on 01 Jun 2012, accepted on 05 Jul 2012 and first published on 06 Jul 2012


Article type: Communication
DOI: 10.1039/C2CC33931E
Citation: Chem. Commun., 2012,48, 8547-8549
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    A lateral flow biosensor for detection of single nucleotide polymorphism by circular strand displacement reaction

    Z. Xiao, P. Lie, Z. Fang, L. Yu, J. Chen, J. Liu, C. Ge, X. Zhou and L. Zeng, Chem. Commun., 2012, 48, 8547
    DOI: 10.1039/C2CC33931E

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