Issue 57, 2012
From the journal:

Chemical Communications

Self-assembling mini cell-penetrating peptides enter by both direct translocation and glycosaminoglycan-dependent endocytosis†

Saskia A. Bode,‡abc   Marion Thévenin,‡abc   Chérine Bechara,abc   Sandrine Sagan,abc   Sarah Bregant,d   Solange Lavielle,abc   Gérard Chassaingabc  and  Fabienne Burlina*abc  

* Corresponding authors

a UPMC Univ Paris 06, UMR 7203, LBM, Paris, France
E-mail: fabienne.burlina@upmc.fr

b CNRS, UMR 7203, LBM, Paris, France

c ENS, UMR 7203, LBM, Paris, France
Tel: +33 144 27 55 09

d CEA, iBiTec-S, SIMOPRO, Gif-sur-Yvette, France

Abstract

A small library of cell-penetrating peptides (CPPs) containing a minimized cationic domain and a lipophilic domain of different size was studied. CPPs that could self-assemble were found to enter cells more efficiently, triggering a glycosaminoglycan-dependent pathway.

Graphical abstract: Self-assembling mini cell-penetrating peptides enter by both direct translocation and glycosaminoglycan-dependent endocytosis

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Article information

DOI
https://doi.org/10.1039/C2CC33240J
Article type
Communication
Submitted
23 Mar 2012
Accepted
28 May 2012
First published
29 May 2012

Chem. Commun., 2012,48, 7179-7181

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Self-assembling mini cell-penetrating peptides enter by both direct translocation and glycosaminoglycan-dependent endocytosis

S. A. Bode, M. Thévenin, C. Bechara, S. Sagan, S. Bregant, S. Lavielle, G. Chassaing and F. Burlina, Chem. Commun., 2012, 48, 7179 DOI: 10.1039/C2CC33240J

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