Issue 47, 2012

Cu(ii)-catalyzed C–H (SP3) oxidation and C–N cleavage: base-switched methylenation and formylation using tetramethylethylenediamine as a carbon source

Abstract

Base-switched methylenation and formylation using tetramethylethylenediamine (TMEDA) as a carbon source have been achieved under mild conditions, catalyzed by CuCl2, with atmospheric oxygen as oxidant. Bisindolylmethanes, diphenylmethanes and 3-formylindoles were synthesized with excellent regioselectivity and good yield.

Graphical abstract: Cu(ii)-catalyzed C–H (SP3) oxidation and C–N cleavage: base-switched methylenation and formylation using tetramethylethylenediamine as a carbon source

Supplementary files

Article information

Article type
Communication
Submitted
19 Mar 2012
Accepted
20 Apr 2012
First published
23 Apr 2012

Chem. Commun., 2012,48, 5928-5930

Cu(II)-catalyzed C–H (SP3) oxidation and C–N cleavage: base-switched methylenation and formylation using tetramethylethylenediamine as a carbon source

L. Zhang, C. Peng, D. Zhao, Y. Wang, H. Fu, Q. Shen and J. Li, Chem. Commun., 2012, 48, 5928 DOI: 10.1039/C2CC32009F

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