Issue 45, 2012
From the journal:

Chemical Communications

Sequence-specific synthesis of macromolecules using DNA-templated chemistry†‡

Phillip J. Milnes,a   Mireya L. McKee,b   Jonathan Bath,b   Lijiang Song,a   Eugen Stulz,c   Andrew J. Turberfield*b  and  Rachel K. O'Reilly*a  

* Corresponding authors

a Department of Chemistry, University of Warwick, Coventry, UK
E-mail: rachel.oreilly@warwick.ac.uk

b University of Oxford, Department of Physics, Clarendon Laboratory, Oxford, UK
E-mail: a.turberfield@physics.ox.ac.uk

c School of Chemistry, University of Southampton, Highfield, Southampton, UK

Abstract

Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.

Graphical abstract: Sequence-specific synthesis of macromolecules using DNA-templated chemistry

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Article information

DOI
https://doi.org/10.1039/C2CC31975F
Article type
Communication
Submitted
18 Mar 2012
Accepted
16 Apr 2012
First published
17 Apr 2012

Chem. Commun., 2012,48, 5614-5616

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Sequence-specific synthesis of macromolecules using DNA-templated chemistry

P. J. Milnes, M. L. McKee, J. Bath, L. Song, E. Stulz, A. J. Turberfield and R. K. O'Reilly, Chem. Commun., 2012, 48, 5614 DOI: 10.1039/C2CC31975F

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