Issue 43, 2012

Asymmetric aldol reactionvia memory of chirality

Abstract

Asymmetric aldol reactions of α-amino acid derivatives via memory of chirality were developed. Chiral oxazolidones with contiguous tetra- and trisubstituted chiral centers were obtained in 78–94% ee by the asymmetric aldol reaction followed by intramolecular acylation.

Graphical abstract: Asymmetric aldol reaction via memory of chirality

  • This article is part of the themed collection: Chirality

Supplementary files

Article information

Article type
Communication
Submitted
27 Feb 2012
Accepted
03 Apr 2012
First published
03 Apr 2012

Chem. Commun., 2012,48, 5346-5348

Asymmetric aldol reaction via memory of chirality

H. Watanabe, T. Yoshimura, S. Kawakami, T. Sasamori, N. Tokitoh and T. Kawabata, Chem. Commun., 2012, 48, 5346 DOI: 10.1039/C2CC31447A

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