Issue 17, 2012
From the journal:

Chemical Communications

A Seoul-Fluor-based bioprobe for lipid droplets and its application in image-based high throughput screening†

Eunha Kim,‡a   Sanghee Lee‡a  and  Seung Bum Park*ab  

* Corresponding authors

a Department of Chemistry/Bio-MAX Institute, Seoul National University, Seoul 151-747, Korea

b Department of Biophysics and Chemical Biology, Seoul National University, Seoul 151-747, Korea
E-mail: sbpark@snu.ac.kr
Fax: +82 2 884 4025
Tel: +82 2 880 9090

Abstract

We developed a novel fluorescent bioprobe (SF44) that can specifically visualize the cellular lipid droplets in in vitro and in vivo systems and illustrated the mechanistic rationale of its fluorogenic property. Its application to image-based high throughput screening led us to the identification of a new small-molecule modulator of lipid droplet formation.

Graphical abstract: A Seoul-Fluor-based bioprobe for lipid droplets and its application in image-based high throughput screening

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Article information

DOI
https://doi.org/10.1039/C2CC17496K
Article type
Communication
Submitted
01 Dec 2011
Accepted
05 Jan 2012
First published
10 Jan 2012

Chem. Commun., 2012,48, 2331-2333

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A Seoul-Fluor-based bioprobe for lipid droplets and its application in image-based high throughput screening

E. Kim, S. Lee and S. B. Park, Chem. Commun., 2012, 48, 2331 DOI: 10.1039/C2CC17496K

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