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Issue 11, 2012
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Hexafluorobenzene: a powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction

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Abstract

A dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available α,α-L-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a medium. DFT calculations were performed to clarify the origin of stereoselectivity and the role of C6F6.

Graphical abstract: Hexafluorobenzene: a powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction

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Publication details

The article was received on 30 Nov 2011, accepted on 08 Dec 2011 and first published on 12 Dec 2011


Article type: Communication
DOI: 10.1039/C2CC17488J
Citation: Chem. Commun., 2012,48, 1650-1652
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    Hexafluorobenzene: a powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction

    A. Lattanzi, C. De Fusco, A. Russo, A. Poater and L. Cavallo, Chem. Commun., 2012, 48, 1650
    DOI: 10.1039/C2CC17488J

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