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Issue 9, 2012
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A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe

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Abstract

The synthesis of a trifluoromethylphenyl diazirine photoaffinity probe of the cytohesin inhibitor SecinH3 is described. The probe exhibits improved labelling efficiency over a benzophenone-based probe and thus is more suitable for photoaffinity labelling in complex biological samples.

Graphical abstract: A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe

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Publication details

The article was received on 18 Oct 2011, accepted on 28 Nov 2011 and first published on 28 Nov 2011


Article type: Communication
DOI: 10.1039/C2CC16477A
Citation: Chem. Commun., 2012,48, 1272-1274
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    A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe

    B. Albertoni, J. S. Hannam, D. Ackermann, A. Schmitz and M. Famulok, Chem. Commun., 2012, 48, 1272
    DOI: 10.1039/C2CC16477A

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