Issue 20, 2012
From the journal:

Chemical Communications

Simplifying native chemical ligation with an N-acylsulfonamide linker†

Fabienne Burlina,a   Caroline Morris,b   Raymond Behrendt,c   Peter White*d  and  John Offer*b  

* Corresponding authors

a UPMC Univ Paris 06, CNRS, ENS, UMR 7203 Laboratoire des Biomolécules, 4 place Jussieu, 75005 Paris, France

b Division of Physical Biochemistry, MRC National Institute for Medical Research, Mill Hill, London, UK
E-mail: joffer@nimr.mrc.ac.uk
Tel: +44 2088162082

c Merck & Cie, Im Laternenacker 5, 8200 Schaffhausen, Switzerland

d Merck Chemicals, Padge Road, Beeston, Notts, NG9 2JR UK
E-mail: peter.white@merckgroup.com

Abstract

We report a simplified procedure for the chemical ligation of peptides by using the sulfamylbutyryl linker as a mildly activating group capable of participating in ligation. When the peptidyl N-methylsulfonamide is directly added with excess thiols to ligation reactions, the speed of reaction is comparable to native chemical ligation.

Graphical abstract: Simplifying native chemical ligation with an N-acylsulfonamide linker

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC15911B
Article type
Communication
Submitted
22 Sep 2011
Accepted
11 Jan 2012
First published
31 Jan 2012

Chem. Commun., 2012,48, 2579-2581

Permissions

Request permissions

Simplifying native chemical ligation with an N-acylsulfonamide linker

F. Burlina, C. Morris, R. Behrendt, P. White and J. Offer, Chem. Commun., 2012, 48, 2579 DOI: 10.1039/C2CC15911B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements