Issue 12, 2012
From the journal:

Chemical Communications

A label-free electrochemical assay for quantification of gene-specific methylation in a nucleic acid sequence†

Zong Dai,*a   Xiao Hu,a   Hai Wua  and  Xiaoyong Zoua  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, P. R. China
E-mail: daizong@mail.sysu.edu.cn
Fax: +86 20 84112245
Tel: +86 20 84114919

Abstract

A label-free electrochemical method is developed for simple and convenient quantification of gene-specific DNA hypermethylation in a DNA sequence without PCR amplification, bisulfite conversion or labeling processes.

Graphical abstract: A label-free electrochemical assay for quantification of gene-specific methylation in a nucleic acid sequence

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Article information

DOI
https://doi.org/10.1039/C2CC15398J
Article type
Communication
Submitted
30 Aug 2011
Accepted
08 Dec 2011
First published
05 Jan 2012

Chem. Commun., 2012,48, 1769-1771

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A label-free electrochemical assay for quantification of gene-specific methylation in a nucleic acid sequence

Z. Dai, X. Hu, H. Wu and X. Zou, Chem. Commun., 2012, 48, 1769 DOI: 10.1039/C2CC15398J

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