Issue 48, 2011
From the journal:

Chemical Communications

Solid-phase synthesis of arginine-based double-tailed cationic lipopeptides: potent nucleic acid carriers†

Aleksandra Liberska,a   Annamaria Lilienkampf,a   Asier Unciti-Broceta*bc  and  Mark Bradley*a  

* Corresponding authors

a School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh, UK
E-mail: mark.bradley@ed.ac.uk

b Edinburgh Cancer Research Centre, MRC IGMM, University of Edinburgh, Edinburgh, UK
E-mail: asier.ub@ed.ac.uk

c Deliverics Ltd, NB1, Joseph Black Building, Edinburgh, UK

Abstract

Herein we report a highly-efficient solid-phase strategy for the modular synthesis of 63 double-tailed lipid-peptide conjugates and their application in DNA delivery.

Graphical abstract: Solid-phase synthesis of arginine-based double-tailed cationic lipopeptides: potent nucleic acid carriers

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Article information

DOI
https://doi.org/10.1039/C1CC15805H
Article type
Communication
Submitted
19 Sep 2011
Accepted
14 Oct 2011
First published
01 Nov 2011

Chem. Commun., 2011,47, 12774-12776

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Solid-phase synthesis of arginine-based double-tailed cationic lipopeptides: potent nucleic acid carriers

A. Liberska, A. Lilienkampf, A. Unciti-Broceta and M. Bradley, Chem. Commun., 2011, 47, 12774 DOI: 10.1039/C1CC15805H

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