Issue 47, 2011

Zwitterionic sulfobetaine lipids that form vesicles with salt-dependent thermotropic properties

Abstract

We describe a class of zwitterionic sulfobetaine (SB) lipids with fascinating salt-dependent properties. SB lipids are zwitter-neutral across a broad pH range; however they have negative surface potentials in the presence of anions and two salt-dependent transition temperatures. These new SB lipids provide insight on the role of charge orientation at the membrane interface and may be useful components in drug delivery systems.

Graphical abstract: Zwitterionic sulfobetaine lipids that form vesicles with salt-dependent thermotropic properties

Supplementary files

Article information

Article type
Communication
Submitted
19 Sep 2011
Accepted
13 Oct 2011
First published
02 Nov 2011

Chem. Commun., 2011,47, 12613-12615

Zwitterionic sulfobetaine lipids that form vesicles with salt-dependent thermotropic properties

E. K. Perttu and F. C. Szoka, Chem. Commun., 2011, 47, 12613 DOI: 10.1039/C1CC15804J

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