PdCl2(dppf)-catalyzed in situ coupling of 2-hydroxypyridines with aryl boronic acids mediated by PyBroP and the one-pot chemo- and regioselective construction of two distinct aryl–aryl bonds

Shui-Ming Li; Jie Huang; Guo-Jun Chen; Fu-She Han

doi:10.1039/C1CC15753A

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PdCl₂(dppf)-catalyzed in situ coupling of 2-hydroxypyridines with aryl boronic acids mediated by PyBroP and the one-pot chemo- and regioselective construction of two distinct aryl–aryl bonds†

Shui-Ming Li,^a Jie Huang,^a Guo-Jun Chen^a and Fu-She Han*^ab

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* Corresponding authors

^a Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, Jilin, China
E-mail: fshan@ciac.jl.cn
Tel: +86-431-8526-2936

^b State Key Laboratory of Fine Chemicals, Dalian 116024, China

Abstract

We present a PdCl₂(dppf)-catalyzed synthesis of 2-arylated pyridine derivatives via the in situ coupling of 2-OH pyridines and boronic acids mediated by PyBroP. In addition, the highly chemo- and regioselective construction of two different aryl–aryl bonds via a one-pot operation has also been demonstrated by the orthogonal use of this method with the Ni-catalyzed Suzuki–Miyaura coupling of phenols.

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Article information

DOI: https://doi.org/10.1039/C1CC15753A
Article type: Communication
Submitted: 17 Sep 2011
Accepted: 16 Oct 2011
First published: 02 Nov 2011

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Chem. Commun., 2011,47, 12840-12842

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PdCl₂(dppf)-catalyzed in situ coupling of 2-hydroxypyridines with aryl boronic acids mediated by PyBroP and the one-pot chemo- and regioselective construction of two distinct aryl–aryl bonds

S. Li, J. Huang, G. Chen and F. Han, Chem. Commun., 2011, 47, 12840 DOI: 10.1039/C1CC15753A

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