Issue 47, 2011
From the journal:

Chemical Communications

Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides†

Marco Bartoloni,a   Rameshwar U. Kadam,a   Julian Schwartz,a   Julien Furrer,a   Tamis Darbrea  and  Jean-Louis Reymond*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH-3012 Berne, Switzerland
E-mail: jean-louis.reymond@ioc.unibe.ch
Fax: +41 31 631 80 57
Tel: +41 31 631 43 25

Abstract

Norbornapeptides (bicyclo[2.2.1]heptapeptides) and related bicyclic homodetic peptides were prepared by solid-phase peptide synthesis using an orthogonal protection scheme. These conformationally rigid peptides cover an almost pristine area of peptide topological space and adopt globular shapes similar to those of short α-helical peptides.

Graphical abstract: Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC15704C
Article type
Communication
Submitted
15 Sep 2011
Accepted
11 Oct 2011
First published
27 Oct 2011

Chem. Commun., 2011,47, 12634-12636

Permissions

Request permissions

Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides

M. Bartoloni, R. U. Kadam, J. Schwartz, J. Furrer, T. Darbre and J. Reymond, Chem. Commun., 2011, 47, 12634 DOI: 10.1039/C1CC15704C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements