Issue 39, 2011
From the journal:

Chemical Communications

Novel hybrid vesicles co-assembled from a cationic lipid and PAAc-g-mPEG with pH-triggered transmembrane channels for controlled drug release†

Yi-Fong Huang,‡a   Wen-Hsuan Chiang,‡b   Pei-Ling Tsai,a   Chorng-Shyan Chernc  and  Hsin-Cheng Chiu*b  

* Corresponding authors

a Department of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan

b Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300, Taiwan
E-mail: hscchiu@mx.nthu.edu.tw
Fax: +886 35718649
Tel: +886 35750829

c Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 106, Taiwan

Abstract

This work presents an important example of novel hybrid vesicles with pH-triggered transmembrane channels prepared by co-assembly of poly(acrylic acid)-g-poly(monomethoxy ethylene glycol) (PAAc-g-mPEG) with a cationic lipid, didodecyldimethylammonium bromide (DDAB), via electrostatic interaction for effective doxorubicin (DOX) release.

Graphical abstract: Novel hybrid vesicles co-assembled from a cationic lipid and PAAc-g-mPEG with pH-triggered transmembrane channels for controlled drug release

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Article information

DOI
https://doi.org/10.1039/C1CC14793E
Article type
Communication
Submitted
03 Aug 2011
Accepted
02 Sep 2011
First published
12 Sep 2011

Chem. Commun., 2011,47, 10978-10980

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Novel hybrid vesicles co-assembled from a cationic lipid and PAAc-g-mPEG with pH-triggered transmembrane channels for controlled drug release

Y. Huang, W. Chiang, P. Tsai, C. Chern and H. Chiu, Chem. Commun., 2011, 47, 10978 DOI: 10.1039/C1CC14793E

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