Issue 37, 2011

A highly efficient TBAF-promoted intramolecular cyclization of gem-dibromoolefins for the synthesis of 2-bromobenzofurans(thiophenes)

Abstract

A highly efficient tetra-(n-butyl)ammonium fluoride (TBAF)-promoted intramolecular cyclization of gem-dibromoolefins has been developed for the synthesis of 2-bromobenzofused heterocycles. The reaction provides a convenient approach to 2-bromobenzofurans(thiophenes) from the corresponding readily available gem-dibromovinyl substrates without a metal.

Graphical abstract: A highly efficient TBAF-promoted intramolecular cyclization of gem-dibromoolefins for the synthesis of 2-bromobenzofurans(thiophenes)

Supplementary files

Article information

Article type
Communication
Submitted
03 Jul 2011
Accepted
04 Aug 2011
First published
22 Aug 2011

Chem. Commun., 2011,47, 10476-10478

A highly efficient TBAF-promoted intramolecular cyclization of gem-dibromoolefins for the synthesis of 2-bromobenzofurans(thiophenes)

W. Chen, Y. Zhang, L. Zhang, M. Wang and L. Wang, Chem. Commun., 2011, 47, 10476 DOI: 10.1039/C1CC13967C

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