Issue 31, 2011
From the journal:

Chemical Communications

Copper-catalyzed N-arylation of amines with part-per-million catalyst loadings under air at room temperature†

Ruilong Xie,ab   Hua Fu*a  and  Yun Ling*b  

* Corresponding authors

a Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
E-mail: fuhua@mail.tsinghua.edu.cn

b Key Laboratory of Pesticide Chemistry and Application (Ministry of Agriculture), Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, P. R. China
E-mail: lyun@cau.edu.cn

Abstract

An efficient copper-catalyzed method for N-arylation of amines has been developed with part-per-million catalyst loadings at room temperature under air. Reactions of substituted (E)-1-(2-halophenyl)alkanone oximes with aliphatic amines or aromatic amines provided the N-arylation products in good to excellent yields.

Graphical abstract: Copper-catalyzed N-arylation of amines with part-per-million catalyst loadings under air at room temperature

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Article information

DOI
https://doi.org/10.1039/C1CC13516C
Article type
Communication
Submitted
14 Jun 2011
Accepted
21 Jun 2011
First published
05 Jul 2011

Chem. Commun., 2011,47, 8976-8978

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Copper-catalyzed N-arylation of amines with part-per-million catalyst loadings under air at room temperature

R. Xie, H. Fu and Y. Ling, Chem. Commun., 2011, 47, 8976 DOI: 10.1039/C1CC13516C

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