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Issue 29, 2011
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Ultrasensitive DNA detection based on Au nanoparticles and isothermal circular double-assisted electrochemiluminescence signal amplification

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Abstract

We report here an ultrasensitive DNA detection approach which combines Au NPs enhanced electrochemiluminescence (ECL) of the CdS nanocrystal (NC) film with isothermal circular amplification reaction of polymerase and nicking endonuclease (NEase). By the double-signal amplification, this approach could sensitively respond down to 5 aM DNA.

Graphical abstract: Ultrasensitive DNA detection based on Au nanoparticles and isothermal circular double-assisted electrochemiluminescence signal amplification

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Publication details

The article was received on 26 Apr 2011, accepted on 07 Jun 2011, published on 21 Jun 2011 and first published online on 21 Jun 2011


Article type: Communication
DOI: 10.1039/C1CC12413G
Citation: Chem. Commun., 2011,47, 8358-8360
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    Ultrasensitive DNA detection based on Au nanoparticles and isothermal circular double-assisted electrochemiluminescence signal amplification

    H. Zhou, J. Liu, J. Xu and H. Chen, Chem. Commun., 2011, 47, 8358
    DOI: 10.1039/C1CC12413G

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