Issue 21, 2011
From the journal:

Chemical Communications

Synthesis of thiophosphoramidates in water: Click chemistry for phosphates†

Milena Trmčića  and  David R. W. Hodgson*a  

* Corresponding authors

a Department of Chemistry, Science Laboratories, Durham University, South Road, Durham, UK
E-mail: d.r.w.hodgson@durham.ac.uk

Abstract

An aqueous method for the preparation of N,S-dialkyl thiophosphoramidates is reported. Thiophosphorylation of alkylamines was performed using SPCl3 in aqueous reaction media, and the resulting thiophosphoramidate-S-anions were S-alkylated with soft electrophiles. Ranges of amines and electrophiles were explored.

Graphical abstract: Synthesis of thiophosphoramidates in water: Click chemistry for phosphates

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Article information

DOI
https://doi.org/10.1039/C1CC11586C
Article type
Communication
Submitted
18 Mar 2011
Accepted
08 Apr 2011
First published
26 Apr 2011

Chem. Commun., 2011,47, 6156-6158

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Synthesis of thiophosphoramidates in water: Click chemistry for phosphates

M. Trmčić and D. R. W. Hodgson, Chem. Commun., 2011, 47, 6156 DOI: 10.1039/C1CC11586C

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