Issue 26, 2011

Homo-DNA templated chemistry and its application to nucleic acid sensing

Abstract

We have investigated the homo-DNA templated Staudinger reduction of the profluorophore rhodamine azide and have applied this reaction to the detection of natural DNA with a hybrid homo-DNA/DNA molecular beacon. In this system the sensing and the reporting unit are bioorthogonal to each other which facilitates sequence design and increases fidelity.

Graphical abstract: Homo-DNA templated chemistry and its application to nucleic acid sensing

Supplementary files

Article information

Article type
Communication
Submitted
14 Mar 2011
Accepted
19 Apr 2011
First published
09 May 2011

Chem. Commun., 2011,47, 7494-7496

Homo-DNA templated chemistry and its application to nucleic acid sensing

M. Stoop and C. J. Leumann, Chem. Commun., 2011, 47, 7494 DOI: 10.1039/C1CC11469G

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