Issue 17, 2011
From the journal:

Chemical Communications

The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions†

Elzbieta Sochacka,a   Karina Kraszewska,a   Marek Sochacki,b   Milena Sobczak,c   Magdalena Janickac  and  Barbara Nawrot*c  

* Corresponding authors

a Institute of Organic Chemistry, Technical University of Lodz, Zeromskiego 116, 90-924 Lodz, Poland

b Laboratory for Analysis of Organic Compounds and Polymers, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland

c Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland
E-mail: bnawrot@bio.cbmm.lodz.pl
Fax: +48 42 681 54 83
Tel: +48 42 681 69 70

Abstract

The 2-thiouridine (S2U) unit in the RNA strand is predominantly desulfured with H2O2 to 4-pyrimidinone nucleoside (H2U). The resulting H2U-RNA exhibits significantly lower binding affinity to its complementary strand and in certain conditions undergoes strand scission. These results may explain the tRNA loss of biological function in oxidative stress conditions.

Graphical abstract: The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions

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Article information

DOI
https://doi.org/10.1039/C1CC10973A
Article type
Communication
Submitted
18 Feb 2011
Accepted
10 Mar 2011
First published
24 Mar 2011

Chem. Commun., 2011,47, 4914-4916

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The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions

E. Sochacka, K. Kraszewska, M. Sochacki, M. Sobczak, M. Janicka and B. Nawrot, Chem. Commun., 2011, 47, 4914 DOI: 10.1039/C1CC10973A

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