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Issue 17, 2011
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X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG)

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Abstract

The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)2 DNA sequence were obtained by X-ray diffraction analysis at 2.3 Å resolution. Both drugs join the end of two “two-molecules” DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)2 DNA in its iminium form.

Graphical abstract: X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG)

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Publication details

The article was received on 18 Feb 2011, accepted on 04 Mar 2011 and first published on 22 Mar 2011


Article type: Communication
DOI: 10.1039/C1CC10971E
Citation: Chem. Commun., 2011,47, 4917-4919
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    X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG)

    M. Ferraroni, C. Bazzicalupi, A. R. Bilia and P. Gratteri, Chem. Commun., 2011, 47, 4917
    DOI: 10.1039/C1CC10971E

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