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Issue 19, 2011
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Highly enantioselective zinc/BINOL-catalyzed alkynylation of α-ketoimine ester: a new entry to optically active quaternary α-CF3 α-amino acids

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Abstract

An effective method for highly enantioselective alkynylation of ketoimine (α-trifluoromethyl ketoimine ester) has been developed via a zinc/BINOL catalyzed process. This protocol provides a useful and facile access to optically active quaternary α-trifluoromethyl α-amino acids and related derivatives of interest in life sciences.

Graphical abstract: Highly enantioselective zinc/BINOL-catalyzed alkynylation of α-ketoimine ester: a new entry to optically active quaternary α-CF3 α-amino acids

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Publication details

The article was received on 20 Jan 2011, accepted on 10 Mar 2011 and first published on 05 Apr 2011


Article type: Communication
DOI: 10.1039/C1CC10403A
Citation: Chem. Commun., 2011,47, 5587-5589
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    Highly enantioselective zinc/BINOL-catalyzed alkynylation of α-ketoimine ester: a new entry to optically active quaternary α-CF3 α-amino acids

    G. Huang, J. Yang and X. Zhang, Chem. Commun., 2011, 47, 5587
    DOI: 10.1039/C1CC10403A

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