Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes

Enzo Terreno; Cinzia Boffa; Valeria Menchise; Franco Fedeli; Carla Carrera; Daniela Delli Castelli; Giuseppe Digilio; Silvio Aime

doi:10.1039/C1CC10172B

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Gadolinium-doped LipoCEST agents: a potential novel class of dual ¹H-MRI probes†

Enzo Terreno,*^a Cinzia Boffa,^a Valeria Menchise,^b Franco Fedeli,^c Carla Carrera,^c Daniela Delli Castelli,^a Giuseppe Digilio^d and Silvio Aime^a

Author affiliations

* Corresponding authors

^a Department of Chemistry IFM and Molecular & Preclinical Imaging Centres, University of Torino, via Nizza 52, Torino, Italy
E-mail: enzo.terreno@unito.it
Fax: +39 011-6706487
Tel: +39 011-6706452

^b Institute for Biostructures and Bioimages (CNR), c/o Molecular Biotechnology Center, University of Torino, via Nizza 52, Torino, Italy

^c Laboratory of Integrated and Advanced Methodologies, Bioindustry Park of Canavese, via Ribes, 5, Colleretto Giacosa (TO), Italy

^d Department of Life and Environmental Sciences, University of Eastern Piedmont “A. Avogadro”, Alessandria, Italy

Abstract

A novel class of paramagnetic liposome-based systems acting as dual T₁ and CEST ¹H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T₁ contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.

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Article information

DOI: https://doi.org/10.1039/C1CC10172B
Article type: Communication
Submitted: 10 Jan 2011
Accepted: 22 Feb 2011
First published: 15 Mar 2011

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Chem. Commun., 2011,47, 4667-4669

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Gadolinium-doped LipoCEST agents: a potential novel class of dual ¹H-MRI probes

E. Terreno, C. Boffa, V. Menchise, F. Fedeli, C. Carrera, D. D. Castelli, G. Digilio and S. Aime, Chem. Commun., 2011, 47, 4667 DOI: 10.1039/C1CC10172B

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