Issue 19, 2011

Artificial synthetic receptors as regulators of protein activity

Abstract

This article discusses most recent work and progress in the direction of a rational design of small molecule receptors that efficiently interfere with the biological function of a particular receptor or enzyme—some of which are therapeutically relevant. More specifically, the following topics are highlighted here: the inhibition of voltage-dependent potassium channels of the Kv1.x family by designed porphyrin and calix[4]arene ligands, the structural and functional recovery of the tetramerization domain of mutated P53 protein by tailored calix[4]arene ligands and the control over LDH activity by supramolecular signaling. Finally a new way to modulate NAD+-dependent enzymatic activities by molecular clips and tweezers is presented.

Graphical abstract: Artificial synthetic receptors as regulators of protein activity

Article information

Article type
Feature Article
Submitted
27 Dec 2010
Accepted
18 Feb 2011
First published
10 Mar 2011

Chem. Commun., 2011,47, 5376-5383

Artificial synthetic receptors as regulators of protein activity

S. Dutt, C. Wilch and T. Schrader, Chem. Commun., 2011, 47, 5376 DOI: 10.1039/C0CC05812B

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