Issue 13, 2011
From the journal:

Chemical Communications

Single atom modification leads to enhanced nucleotideself-assembly: the role of cation bridging†

Irene C. M. Kwan,a   Richard J. Delley,b   David R. W. Hodgsonb  and  Gang Wu*a  

* Corresponding authors

a Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, Canada
E-mail: gang.wu@chem.queensu.ca

b Department of Chemistry, University Science Laboratories, South Road, Durham, UK
E-mail: d.r.w.hodgson@durham.ac.uk

Abstract

We report that the ability of disodium 5′-deoxy-5′-thioguanosine-5′-monophosphate, Na2(5′-GSMP), to self-associate into a helical G-quadruplex structure in aqueous solution at pH 8 is significantly higher than that of disodium guanosine-5′-monophosphate, Na2(5′-GMP), which supports our earlier hypothesis regarding the importance of cation bridging.

Graphical abstract: Single atom modification leads to enhanced nucleotide self-assembly: the role of cation bridging

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Article information

DOI
https://doi.org/10.1039/C0CC05654E
Article type
Communication
Submitted
17 Dec 2010
Accepted
28 Jan 2011
First published
18 Feb 2011

Chem. Commun., 2011,47, 3882-3884

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Single atom modification leads to enhanced nucleotide self-assembly: the role of cation bridging

I. C. M. Kwan, R. J. Delley, D. R. W. Hodgson and G. Wu, Chem. Commun., 2011, 47, 3882 DOI: 10.1039/C0CC05654E

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