Issue 16, 2011
From the journal:

Chemical Communications

Organocatalytic chemoselective asymmetric N-allylic alkylation of enamides†

Ji-Rong Huang,a   Hai-Lei Cui,a   Jie Lei,a   Xun-Hao Suna  and  Ying-Chun Chen*ab  

* Corresponding authors

a Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
E-mail: ycchenhuaxi@yahoo.com.cn
Fax: +86 28 85502609

b State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China

Abstract

The first Lewis base-catalysed chemoselective asymmetric N-allylic alkylation of enamides with Morita–Baylis–Hillman carbonates has been developed, which affords multifunctional products in moderate to high enantioselectivity (up to 92% ee).

Graphical abstract: Organocatalytic chemoselective asymmetric N-allylic alkylation of enamides

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Article information

DOI
https://doi.org/10.1039/C0CC05616B
Article type
Communication
Submitted
16 Dec 2010
Accepted
01 Mar 2011
First published
16 Mar 2011

Chem. Commun., 2011,47, 4784-4786

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Organocatalytic chemoselective asymmetric N-allylic alkylation of enamides

J. Huang, H. Cui, J. Lei, X. Sun and Y. Chen, Chem. Commun., 2011, 47, 4784 DOI: 10.1039/C0CC05616B

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