Cleavable β-cyclodextrin nanocapsules incorporating GdIII-chelates as bioresponsive MRI probes

Jonathan Martinelli; Marianna Fekete; Lorenzo Tei; Mauro Botta

doi:10.1039/C0CC05428C

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Cleavable β-cyclodextrin nanocapsules incorporating Gd^III-chelates as bioresponsive MRI probes†

Jonathan Martinelli,^a Marianna Fekete,^a Lorenzo Tei^a and Mauro Botta*^a

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* Corresponding authors

^a Dipartimento di Scienze dell'Ambiente e della Vita, Università del Piemonte Orientale “Amedeo Avogadro”, Viale T. Michel 11, 15121 Alessandria, Italy
E-mail: mauro.botta@mfn.unipmn.it
Fax: +39 0131360250
Tel: +39 0131360253

Abstract

Perthiolated β-cyclodextrin-based nanocapsules incorporating diaquo Gd^III-complexes represent a promising new type of bioresponsive MRI contrast agent, showing a pronounced relaxivity change upon degradation in a reducing environment.

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Article information

DOI: https://doi.org/10.1039/C0CC05428C
Article type: Communication
Submitted: 07 Dec 2010
Accepted: 11 Jan 2011
First published: 26 Jan 2011

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Chem. Commun., 2011,47, 3144-3146

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Cleavable β-cyclodextrin nanocapsules incorporating Gd^III-chelates as bioresponsive MRI probes

J. Martinelli, M. Fekete, L. Tei and M. Botta, Chem. Commun., 2011, 47, 3144 DOI: 10.1039/C0CC05428C

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Chemical Communications