Issue 14, 2011
From the journal:

Chemical Communications

Dye-doped silicananoparticles as efficient labels for glycans†

Xin Wang,a   Olof Ramström*b  and  Mingdi Yan*ab  

* Corresponding authors

a Department of Chemistry, Portland State University, P.O. Box 751, Portland, Oregon, USA
E-mail: yanm@pdx.edu
Fax: +01 5037259525
Tel: +01 5037255756

b Department of Chemistry, KTH-Royal Institute of Technology, Teknikringen 30, S-10044 Stockholm, Sweden
E-mail: ramstrom@kth.se
Fax: +46 87912333
Tel: +46 87906915

Abstract

We report that dye-doped fluorescent silica nanoparticles (FSNPs) are highly efficient labels for glycans. Mono- and oligo-saccharides were conjugated to FSNPs using a general photocoupling chemistry. FSNP-labeled glycans were applied to image and detect bacteria, and to study carbohydrate–lectin interactions on a lectin microarray.

Graphical abstract: Dye-doped silica nanoparticles as efficient labels for glycans

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Article information

DOI
https://doi.org/10.1039/C0CC05299J
Article type
Communication
Submitted
01 Dec 2010
Accepted
10 Feb 2011
First published
07 Mar 2011

Chem. Commun., 2011,47, 4261-4263

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Dye-doped silica nanoparticles as efficient labels for glycans

X. Wang, O. Ramström and M. Yan, Chem. Commun., 2011, 47, 4261 DOI: 10.1039/C0CC05299J

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