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Issue 12, 2011
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First one-pot stereoselective synthesis of cis-2,3-dihydro-4-perfluoroalkyl-1H-1,5-benzodiazepines via a catalyst-free three-component reaction

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Abstract

cis-2,3-Dihydro-4-perfluoroalkyl-1H-1,5-benzodiazepines were stereoselectively synthesized using a one-pot, catalyst-free, three-component reaction. This novel, efficient and convenient approach was used to synthesize 22 related products in moderate to excellent yields, demonstrating the scope and potential economic impact of the reaction.

Graphical abstract: First one-pot stereoselective synthesis of cis-2,3-dihydro-4-perfluoroalkyl-1H-1,5-benzodiazepines via a catalyst-free three-component reaction

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Publication details

The article was received on 19 Nov 2010, accepted on 21 Jan 2011 and first published on 07 Feb 2011


Article type: Communication
DOI: 10.1039/C0CC05039C
Citation: Chem. Commun., 2011,47, 3607-3609
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    First one-pot stereoselective synthesis of cis-2,3-dihydro-4-perfluoroalkyl-1H-1,5-benzodiazepines via a catalyst-free three-component reaction

    J. Xu, J. Wei, L. Bian, J. Zhang, J. Chen, H. Deng, X. Wu, H. Zhang and W. Cao, Chem. Commun., 2011, 47, 3607
    DOI: 10.1039/C0CC05039C

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