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Issue 8, 2011
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Discovery of novel anti-HIV active G-quadruplex-forming oligonucleotides

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Abstract

A series of d(5′TGGGAG3′) sequences, 5′-conjugated with a variety of aromatic groups through phosphodiester linkages, were synthesized, showing CD spectra diagnostic of parallel-stranded, tetramolecular G-quadruplex structures. When tested for anti-HIV-1 and HIV-2 activity, potent inhibition of HIV-1 infection in CEM cell cultures was found, associated with high selectivity index values. Surface Plasmon Resonance assays revealed specific binding to HIV-1 gp120 and gp41.

Graphical abstract: Discovery of novel anti-HIV active G-quadruplex-forming oligonucleotides

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Publication details

The article was received on 02 Nov 2010, accepted on 23 Nov 2010 and first published on 16 Dec 2010


Article type: Communication
DOI: 10.1039/C0CC04751A
Citation: Chem. Commun., 2011,47, 2363-2365
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    Discovery of novel anti-HIV active G-quadruplex-forming oligonucleotides

    G. Di Fabio, J. D'Onofrio, M. Chiapparelli, B. Hoorelbeke, D. Montesarchio, J. Balzarini and L. De Napoli, Chem. Commun., 2011, 47, 2363
    DOI: 10.1039/C0CC04751A

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