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Issue 6, 2011
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Coumarinmalonitrile conjugate as a fluorescence turn-on probe for biothiols and its cellular expression

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Abstract

A nonfluorescent coumarin–malonitrile conjugate (1) was transformed into a strongly fluorescent molecule through the Michael addition of a thiol group to the α,β-unsaturated malonitrile of 1. The molecular probe has exhibited a highly selective fluorescence response toward biothiols (Cys, Hcy, GSH) with micromolar sensitivity both in vitro and in vivo.

Graphical abstract: Coumarin–malonitrile conjugate as a fluorescence turn-on probe for biothiols and its cellular expression

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Publication details

The article was received on 27 Sep 2010, accepted on 15 Nov 2010 and first published on 02 Dec 2010


Article type: Communication
DOI: 10.1039/C0CC04092D
Citation: Chem. Commun., 2011,47, 1773-1775
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    Coumarinmalonitrile conjugate as a fluorescence turn-on probe for biothiols and its cellular expression

    H. Kwon, K. Lee and H. Kim, Chem. Commun., 2011, 47, 1773
    DOI: 10.1039/C0CC04092D

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