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Issue 1, 2011
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Direct and efficient N-heterocyclic carbene-catalyzed hydroxymethylation of aldehydes

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Abstract

The N-heterocyclic carbene-catalyzed coupling of several aldehydes with paraformaldehyde is reported, directly providing the corresponding valuable hydroxymethyl ketones. Results of first mechanistic experiments for this remarkably selective transformation are also provided.

Graphical abstract: Direct and efficient N-heterocyclic carbene-catalyzed hydroxymethylation of aldehydes

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Publication details

The article was received on 07 Jul 2010, accepted on 13 Sep 2010 and first published on 01 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC02416C
Citation: Chem. Commun., 2011,47, 573-575
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    Direct and efficient N-heterocyclic carbene-catalyzed hydroxymethylation of aldehydes

    N. Kuhl and F. Glorius, Chem. Commun., 2011, 47, 573
    DOI: 10.1039/C0CC02416C

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