Issue 1, 2011
From the journal:

Chemical Communications

Direct carbon–carbon bond formation via soft enolization: aldol addition of α-halogenated thioesters†‡

Julianne M. Yost,a   Rachel J. Alfie,a   Emily M. Tarsis,a   Insun Chonga  and  Don M. Coltart*a  

* Corresponding authors

a Department of Chemistry, Duke University, Durham, USA
E-mail: don.coltart@duke.edu

Abstract

α-Halo thioesters undergo soft enolization and syn-selective direct aldol addition to aldehydes in the presence of MgBr2·OEt2 and i-Pr2NEt to produce α-halo-β-hydroxy thioesters.

Graphical abstract: Direct carbon–carbon bond formation via soft enolization: aldol addition of α-halogenated thioesters

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Article information

DOI
https://doi.org/10.1039/C0CC02345K
Article type
Communication
Submitted
03 Jul 2010
Accepted
28 Sep 2010
First published
21 Oct 2010

Chem. Commun., 2011,47, 571-572

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Direct carbon–carbon bond formation via soft enolization: aldol addition of α-halogenated thioesters

J. M. Yost, R. J. Alfie, E. M. Tarsis, I. Chong and D. M. Coltart, Chem. Commun., 2011, 47, 571 DOI: 10.1039/C0CC02345K

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