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Issue 47, 2010
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Photochemical cleavage of leader peptides

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Abstract

We report a photolabile linker compatible with Fmoc solid phase peptide synthesis and Cu(I)-catalyzed alkyneazide cycloaddition that allows photochemical cleavage to afford a C-terminal peptide fragment with a native amino terminus.

Graphical abstract: Photochemical cleavage of leader peptides

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Publication details

The article was received on 01 Aug 2010, accepted on 14 Oct 2010 and first published on 02 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC02945A
Citation: Chem. Commun., 2010,46, 8935-8937
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    Photochemical cleavage of leader peptides

    N. Bindman, R. Merkx, R. Koehler, N. Herrman and W. A. van der Donk, Chem. Commun., 2010, 46, 8935
    DOI: 10.1039/C0CC02945A

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