Issue 42, 2010

Gold(i)/Zn(ii) catalyzed tandem hydroamination/annulation reaction of 4-yne-nitriles

Abstract

The tandem hydroamination–annulation reaction of 4-pentyne-nitriles in the presence of amine nucleophiles and a cooperatively operating catalyst system, consisting of Ph3PAuCl and Zn(ClO4)2, provides an efficient route to 2-aminopyrroles. Two regioisomeric 2-aminopyrroles were formed in moderate to good yields.

Graphical abstract: Gold(i)/Zn(ii) catalyzed tandem hydroamination/annulation reaction of 4-yne-nitriles

Supplementary files

Article information

Article type
Communication
Submitted
04 Jul 2010
Accepted
01 Sep 2010
First published
21 Sep 2010

Chem. Commun., 2010,46, 8032-8034

Gold(I)/Zn(II) catalyzed tandem hydroamination/annulation reaction of 4-yne-nitriles

A. S. Demir, M. Emrullahoğlu and K. Buran, Chem. Commun., 2010, 46, 8032 DOI: 10.1039/C0CC02357D

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