Issue 46, 2010

Characterization of xenobiotic reductase A (XenA): study of active site residues, substrate spectrum and stability

Abstract

Xenobiotic reductase A (XenA) has broad catalytic activity and reduces various α,β-unsaturated and nitro compounds with moderate to excellent stereoselectivity. Single mutants C25G and C25V are able to reduce nitrobenzene, a non-active substrate for the wild type, to produce aniline. Total turnover is dominated by chemical rather than thermal instability.

Graphical abstract: Characterization of xenobiotic reductase A (XenA): study of active site residues, substrate spectrum and stability

Supplementary files

Article information

Article type
Communication
Submitted
04 Jul 2010
Accepted
01 Oct 2010
First published
19 Oct 2010

Chem. Commun., 2010,46, 8809-8811

Characterization of xenobiotic reductase A (XenA): study of active site residues, substrate spectrum and stability

Y. Yanto, H. Yu, M. Hall and A. S. Bommarius, Chem. Commun., 2010, 46, 8809 DOI: 10.1039/C0CC02354J

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