Issue 35, 2010
From the journal:

Chemical Communications

A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives†

Karina C. Gornall,a   Siritron Samosorn,ab   Bongkot Tanwirat,b   Apichart Suksamrarn,c   John B. Bremner,a   Michael J. Kelsoa  and  Jennifer L. Beck*a  

* Corresponding authors

a School of Chemistry, University of Wollongong, Wollongong, Australia
E-mail: jbeck@uow.edu.au
Fax: +61 2 4221 4287
Tel: +61 2 4221 4177

b Department of Chemistry, Srinakharinwirot University, Bangkok 10110, Thailand

c Department of Chemistry, Ramkhamhaeng University, Bangkok 10240, Thailand

Abstract

ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands.

Graphical abstract: A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives

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Article information

DOI
https://doi.org/10.1039/C0CC01933J
Article type
Communication
Submitted
17 Jun 2010
Accepted
16 Jul 2010
First published
16 Aug 2010

Chem. Commun., 2010,46, 6602-6604

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A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives

K. C. Gornall, S. Samosorn, B. Tanwirat, A. Suksamrarn, J. B. Bremner, M. J. Kelso and J. L. Beck, Chem. Commun., 2010, 46, 6602 DOI: 10.1039/C0CC01933J

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