Issue 31, 2010

Selective fluorescence detection of cysteine and N-terminal cysteinepeptide residues

Abstract

A new fluorogenic fluorescein derivative containing an α,β-unsaturated aldehyde moiety produces a selective fluorescent signal enhancement in the presence of cysteine or peptides containing N-terminal cysteine residues. The mechanism is based on synergistic covalent and supramolecular interactions.

Graphical abstract: Selective fluorescence detection of cysteine and N-terminal cysteine peptide residues

Supplementary files

Article information

Article type
Communication
Submitted
14 May 2010
Accepted
21 Jun 2010
First published
08 Jul 2010

Chem. Commun., 2010,46, 5707-5709

Selective fluorescence detection of cysteine and N-terminal cysteine peptide residues

S. Lim, J. O. Escobedo, M. Lowry, X. Xu and R. Strongin, Chem. Commun., 2010, 46, 5707 DOI: 10.1039/C0CC01398F

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