Stereoselective Ir(iii)-catalyzed dimerization reaction of enynes: an entry to functionalized polyunsaturated and cyclic systems

Abstract

The Ir(III) complex [Ir₂H₂I₃((rac)-Binap)₂]⁺I⁻ efficiently promotes the selective dimerization of 1,6-, 1,7-enynes and functionalized alkynes. This catalytic process results in the formation of head-to-head isomers with (E)-stereoselectivity. Subsequent Rh-catalyzed cycloisomerization under reductive conditions led to the corresponding 1,2-dialkylidenecyclopentane derivatives.