Issue 19, 2010
From the journal:

Chemical Communications

8-Oxo-7,8-dihydro-2′-deoxyguanosine produces a long-lived charge-separated state during the photosensitized one-electron oxidation of DNA resulting in efficient and exclusive degradation†

Kiyohiko Kawai,*a   Eri Matsutania  and  Tetsuro Majima*b  

* Corresponding authors

a The Institute of Scientific and Industrial Research (SANKEN), Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan
E-mail: kiyohiko@sanken.osaka-u.ac.jp
Fax: +81-6-6879-8499
Tel: +81-6-6879-8496

b The Institute of Scientific and Industrial Research (SANKEN), Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan
E-mail: majima@sanken.osaka-u.ac.jp
Fax: +81-6-6879-8499
Tel: +81-6-6879-8495

Abstract

The kinetics and efficiency of oxidative degradation of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) in DNA during the photosensitized one-electron oxidation of DNA was investigated. The presence of 8-oxodGuo was shown to increase the lifetime of the charge-separated state in DNA by serving as a “hole sink” resulting in efficient and exclusive degradation.

Graphical abstract: 8-Oxo-7,8-dihydro-2′-deoxyguanosine produces a long-lived charge-separated state during the photosensitized one-electron oxidation of DNA resulting in efficient and exclusive degradation

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Article information

DOI
https://doi.org/10.1039/C002810J
Article type
Communication
Submitted
09 Feb 2010
Accepted
12 Mar 2010
First published
29 Mar 2010

Chem. Commun., 2010,46, 3277-3279

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8-Oxo-7,8-dihydro-2′-deoxyguanosine produces a long-lived charge-separated state during the photosensitized one-electron oxidation of DNA resulting in efficient and exclusive degradation

K. Kawai, E. Matsutani and T. Majima, Chem. Commun., 2010, 46, 3277 DOI: 10.1039/C002810J

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