Issue 30, 2010
From the journal:

Chemical Communications

Hairpin DNA coated gold nanoparticles as intracellularmRNAprobes for the detection of tyrosinase gene expression in melanoma cells†

S. Reese Harry,a   Donna J. Hicks,b   Katayoun I. Amirib  and  David W. Wright*a  

* Corresponding authors

a Department of Chemistry, Vanderbilt University, Station B351822, Nashville, USA
E-mail: david.wright@vanderbilt.edu
Fax: +1 615 343 1234
Tel: +1 615 322 2636

b Translational Research Laboratory, Department of Cancer Biology, Vanderbilt School of Medicine, Vanderbilt Ingram Cancer Center, Nashville, USA

Abstract

A new intracellular mRNA imaging probe has been developed that incorporates thiol-terminated hairpin oligonucleotides covalently bound to the surface of citrate-capped gold nanoparticles. The hairpin DNA-coated gold nanoparticles (hAuNPs) positively identifies tyrosinase mRNA in cultured melanoma cells.

Graphical abstract: Hairpin DNA coated gold nanoparticles as intracellular mRNA probes for the detection of tyrosinase gene expression in melanoma cells

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Article information

DOI
https://doi.org/10.1039/C001969K
Article type
Communication
Submitted
29 Jan 2010
Accepted
19 May 2010
First published
04 Jun 2010

Chem. Commun., 2010,46, 5557-5559

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Hairpin DNA coated gold nanoparticles as intracellular mRNA probes for the detection of tyrosinase gene expression in melanoma cells

S. R. Harry, D. J. Hicks, K. I. Amiri and D. W. Wright, Chem. Commun., 2010, 46, 5557 DOI: 10.1039/C001969K

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