Issue 26, 2010

Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

Abstract

The reactions of 6-cyano-1,3-dimethyluracil have been studied as chemical models to illustrate the mechanism for the transformation of 6-cyanouridine 5′-monophosphate (6-CN-UMP) to barbiturate ribonucleoside 5′-monophosphate (BMP) catalyzed by orotidine 5′-monophosphate decarboxylase (ODCase). The results suggest that the Asp residue in the ODCase active site plays the role of a general base in the transformation.

Graphical abstract: Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

Article information

Article type
Communication
Submitted
27 Jan 2010
Accepted
21 Apr 2010
First published
25 May 2010

Chem. Commun., 2010,46, 4821-4823

Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

Y. Wu, C. Liao, C. Jen, Y. Shih and T. Chien, Chem. Commun., 2010, 46, 4821 DOI: 10.1039/C001865A

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