Jump to main content
Jump to site search

Issue 19, 2010
Previous Article Next Article

Concerning the potential reversibility of carbometalation in alkoxide-directed Ti(Oi-Pr)4-mediated reductive cross-coupling of homoallylic alcohols with aromatic imines

Author affiliations

Abstract

In an attempt to understand the nature of selectivity in Ti-mediated reductive cross-coupling between homoallylic alcohols and imines, we investigated whether thermodynamic equilibration of the presumed organometallic intermediate plays a role in selectivity. No evidence could be found for olefin exchange in preformed azatitanacyclopentanes—an observation that is consistent with a model based on kinetically controlled selective carbometalation.

Graphical abstract: Concerning the potential reversibility of carbometalation in alkoxide-directed Ti(Oi-Pr)4-mediated reductive cross-coupling of homoallylic alcohols with aromatic imines

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Jan 2010, accepted on 22 Mar 2010 and first published on 08 Apr 2010


Article type: Communication
DOI: 10.1039/B927430H
Citation: Chem. Commun., 2010,46, 3336-3338
  •   Request permissions

    Concerning the potential reversibility of carbometalation in alkoxide-directed Ti(Oi-Pr)4-mediated reductive cross-coupling of homoallylic alcohols with aromatic imines

    M. Takahashi and G. C. Micalizio, Chem. Commun., 2010, 46, 3336
    DOI: 10.1039/B927430H

Search articles by author

Spotlight

Advertisements