Issue 8, 2010
From the journal:

Chemical Communications

DNA–polyfluorophore excimers as sensitive reporters for esterases and lipases†

Nan Dai,a   Yin Nah Teoa  and  Eric T. Kool*a  

* Corresponding authors

a Department of Chemistry, Stanford University, Stanford, USA
E-mail: kool@stanford.edu
Fax: +1 (650) 725-0259
Tel: +1 (650) 724-4741

Abstract

DNA-scaffolded oligodeoxyriboside fluorophores (ODFs) were used as the reporters in turn-on sensing of enzymatic bond-cleaving activity. A tetramer ODF of pyrene deoxynucleosides displayed high quenching efficiency when conjugated via ester linkages with a dabcyl quencher, and yielded large signal increases with several enzymes in vitro and in intact human cells.

Graphical abstract: DNA–polyfluorophore excimers as sensitive reporters for esterases and lipases

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Article information

DOI
https://doi.org/10.1039/B926338A
Article type
Communication
Submitted
14 Dec 2009
Accepted
14 Jan 2010
First published
22 Jan 2010

Chem. Commun., 2010,46, 1221-1223

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DNA–polyfluorophore excimers as sensitive reporters for esterases and lipases

N. Dai, Y. N. Teo and E. T. Kool, Chem. Commun., 2010, 46, 1221 DOI: 10.1039/B926338A

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