Issue 20, 2010
From the journal:

Chemical Communications

Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implications for copper toxicity in biological systems†

Qingming Wang,a   Liping Lu,*a   Caixia Yuan,a   Kai Pei,a   Zhiwei Liu,b   Maolin Guo*b  and  Miaoli Zhu*ac  

* Corresponding authors

a Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, P. R. China
E-mail: luliping@sxu.edu.cn, miaoli@sxu.edu.cn

b Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, USA
E-mail: mguo@umassd.edu

c State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China

Abstract

A new dinuclear copper complex and several Cu-amino acid complexes inhibit protein tyrosine phosphatase 1B competitively at submicromolar levels, suggesting that copper complexes may interfere with cellular signaling pathways by inhibiting protein tyrosine phosphatases.

Graphical abstract: Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implications for copper toxicity in biological systems

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Article information

DOI
https://doi.org/10.1039/B925603B
Article type
Communication
Submitted
08 Dec 2009
Accepted
17 Mar 2010
First published
09 Apr 2010

Chem. Commun., 2010,46, 3547-3549

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Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implications for copper toxicity in biological systems

Q. Wang, L. Lu, C. Yuan, K. Pei, Z. Liu, M. Guo and M. Zhu, Chem. Commun., 2010, 46, 3547 DOI: 10.1039/B925603B

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