Chiral discrimination of α-amino acids with a C2-symmetric homoditopic receptor

Abstract

Chiral discrimination of α-amino acids has been realized by a C₂-symmetric homoditopic receptor, which is based on a binaphthyl chiral skeleton with 2,2′diisopropoxy substituents and a common binding side arm, (o-carboxamido)-trifluoroacetophenone moiety, in the 3,3′-positions, which recognizes α-amino acids as their amino carboxylate forms through formation of stabilized adducts.