Issue 28, 2009

Mismatch DNA-specific enzymatic cleavage employed in a new method for the electrochemical detection of genetic mutations

Abstract

Utilizing enzymatic mismatched DNA-specific cleavage and electrocatalytic signaling, a new electrochemical method for the detection of DNA mutations was developed and successfully applied to detect various mutations in the BRCA1gene.

Graphical abstract: Mismatch DNA-specific enzymatic cleavage employed in a new method for the electrochemical detection of genetic mutations

Supplementary files

Article information

Article type
Communication
Submitted
09 Apr 2009
Accepted
15 May 2009
First published
09 Jun 2009

Chem. Commun., 2009, 4230-4232

Mismatch DNA-specific enzymatic cleavage employed in a new method for the electrochemical detection of genetic mutations

B. Y. Won, S. C. Shin, W. Chung, S. Shin, D. Cho and H. G. Park, Chem. Commun., 2009, 4230 DOI: 10.1039/B907268C

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